Nudo Mixteco tells three stories that intertwine during the patron saint’s celebration in San Mateo, a village of the Mixtec Oaxaca.
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María buries her mother, her father rejects her, and in uncertainty and pain, she proposes to Piedad, her childhood love, to leave with her.
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Esteban returns after three years to discover that Chabela, his wife, is living with another man; enraged, he calls the village people to prosecute her in an assembly.
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Toña relives her own pain in the face of the abuse of her daughter when she returns to confront her family to protect her.